(SPIA): Signaling Pathway Impact Analysis using combined evidence of pathway over-representation and unusual signaling perturbations

Bioconductor version: Release (2.12)

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the

information form a list of differentially expressed genes and their log fold changes together

with signaling pathways topology, in order to identify the pathways most relevant to the

condition under the study.

Author: Adi Laurentiu Tarca <atarca at med.wayne.edu>, Purvesh Kathri <purvesh at

cs.wayne.edu> and Sorin Draghici <sorin at wayne.edu>

Maintainer: Adi Laurentiu Tarca <atarca at med.wayne.edu>

To install this package, start R and enter:

 source("http://bioconductor.org/biocLite.R")
    biocLite("SPIA")

To cite this package in a publication, start R and enter:

    citation("SPIA")

PDF	R Script	SPIA
PDF		Reference Manual

biocViews	GraphsAndNetworks, Microarray, Software
Version	2.12.0
In Bioconductor since	BioC 2.4 (R-2.9)
License	GPL (>= 2)
Depends	R (>= 2.14.0), graphics, KEGGgraph
Imports	graphics
Suggests	graph, Rgraphviz, hgu133plus2.db
System Requirements
URL	http://bioinformatics.oxfordjournals.org/cgi/reprint/btn577v1
Depends On Me
Imports Me
Suggests Me	graphite, KEGGgraph

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