About Novartis Institute for Biomedical Research:
The Novartis Institutes for BioMedical Research is the global pharmaceutical research organization for Novartis. The NIBR research network is comprised of more than 6,000 scientists, physicians, and business professionals working together across 10 locations around the world to discover innovative medicines that treat diseases with high unmet medical need. Novartis employs more than 2,000 associates in Cambridge, making it the city’s largest private employer and ideally situated in one of the leading life science communities in the world.
NIBR conducts research globally with sites in Emeryville, California; Cambridge, MA; East Hanover, NJ; Basel, Switzerland; Horsham, UK; and Shanghai, China.
About the Next Generation Sequencing Group
The ability to sequence each patient’s genome in great detail, quickly and inexpensively, is changing the practice of medicine. At NIBR, we are dedicated to the development of therapies that improve clinical outcomes for patients. Next generation sequencing and other cutting-edge molecular characterization technologies will be important tools for discovering breakthrough therapeutics, and for delivering the right medicines to the right patients.
NIBR is launching a new Next Generation Diagnostics (NGDx) group at our global headquarters in Cambridge, MA. The NGDx team will leverage cutting-edge technologies such as next generation sequencing for characterizing human tissues, by individual lesions and by pathway signatures relevant to therapeutic response. The goal is to develop a robust and comprehensive molecular profile for each patient. To this end, the group will begin by developing capabilities to characterize therapeutically relevant genetic lesions and pathway signatures in human cancer.
Opportunities exist for genomics scientists, computational biologists, bioinformatics scientists, software and systems engineers, assay development scientists, histopathologists, sample technicians, and biochemists.
Bioinformatics Description:
We are seeking highly motivated bioinformatics scientists at varying levels to join the Novartis Next Generation Sequencing Diagnostics Team. The successful candidates must be self-directed and highly collaborative, and will:
· Build and support cutting-edge pipelines for the analysis and interpretation of next-generation sequencing data
· Analyze large-scale genomic (expression, copy number, mutation, epigenetic) datasets acquired internally and in collaboration with academic and industrial research institutes
· Participate in a rigorous technical development process for genomics platforms, including next-generation sequencing platforms
· Implement state-of-the-art computational methods, and develop innovative methods, toward the development of rigorous diagnostic tests
· Maintain expertise in the science and application of genomic technologies
Qualifications:
To qualify, candidates must have:
· Minimum MS 7+ years’ experience, or PhD 2+ years’ experience working in a bioinformatics research environment
· Strong communication skills and a successful track record of collaborating with cross-functional scientific teams
· Facility with current analysis methods for next-generation sequencing data, and the application of open-source tools such as BWA, GATK, TopHat and CuffLinks
· Experience running large-scale pipelines or simulations in a High Performance Computing environment
· Expertise in machine learning algorithms and their application to biological problems is preferred
· Demonstrated statistical and analytical ability with programming expertise in R, Matlab, or similar
· Demonstrated bioinformatics scripting abilities in languages such as Perl or Python
· Programming experience in Java/C/C++ is a plus
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