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The Personalized Cancer Medicine Partnership (PROFILE) is a collaborative venture between two Harvard Medical School affiliated institutions- the Brigham and Women’s Hospital and the Dana-Farber Cancer Institute. The mission of PROFILE is to advance translational and personalized cancer medicine by implementing tumor genomic profiling on all cancer patients treated at these institutions. PROFILE will employ state-of-the art technology to generate a detailed profile of key “druggable” or otherwise “actionable” cancer genomic alterations in a CLIA-approved and “real-time” process to facilitate rapid clinical application. These cancer genomic profiles will be used to guide patient treatment and/or stratification for clinical trials of novel anticancer agents.

Role and Responsibilities:

This exceptional opportunity offers the chance to work at the forefront of translational cancer technologies and applications. The Computational Biologist will join the current bioinformatics group to analyze and represent genomic data generated by next-generation sequencing (NGS). The Computational Biologist will report to the Group Leader of Bioinformatics and will have the following responsibilities:

Development of novel algorithms and tools for the analysis of somatic and germline genomic alterations.
Identification and evaluation of analysis tools for the identification of variants from NGS data.
Definition, application and validation of computational approaches for cancer genome analysis from next-generation sequencing (and other) data
Analysis of datasets from high-throughput molecular assays utilizing appropriate bioinformatics and/or genetic analyses
Identification of variants in individual samples as well as performing cohort analysis on groups of related samples
Additional tasks including, but not limited to: maintaining awareness of emerging approaches and methods in computational biology as they relate to clinical applications of next-generation sequencing, supporting the visualization and analysis of existing data, developing innovative solutions for the analysis and management of genomic data, including next-generation sequencing data.

Qualifications:

Masters in Computer Science, Bioinformatics, Engineering, Math, Statistics, Physics, or a related quantitative discipline with 3-5 years’ experience, or PhD in the same fields with 1-2 years’ experience required. Advanced statistical and computational data analysis experience using (R, Perl, or MATLAB); demonstrated experience modeling complex multi-dimensional biological data, and strong programming skills (using Java or Perl) in a UNIX/Linux environment are essential. Experience in molecular biology, cancer genomics, or a related field; proven experience in the development and validation of NGS algorithms and knowledge of relevant databases, methods and analytical tools used in next-generation sequencing data analysis/interpretation is highly desirable. Candidate should have the ability to work independently or collaboratively on several concurrent, fast-paced projects. A minimum two-year commitment is required.

How to apply: Interested candidates should provide a resume and a brief cover letter summarizing previous experiences, training, and qualifications, as well as names and contact information for at least two references.

Please contact: Anna Cooley

AnnaC_Cooley@dfci.harvard.edu

(617) 582-8643

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Description:

Johnson & Johnson Pharmaceutical Research & Development L.L.C., a member of Johnson and Johnson's family of companies, is recruiting for a Senior Research Scientist for Molecular Profiling, located in La Jolla, CA.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.

This position is with the Systems Pharmacology and Biomarkers team and requires a highly motivated and skilled Principle Scientist to assist in the early development of innovative therapies for immune diseases such as rheumatoid arthritis, psoriasis, asthma, COPD and inflammatory bowel disease.

This position requires the Senior Research Scientist to accelerate scientific discovery for immunology through the use of informatics in driving innovation and enabling effective decision making. The successful candidate will work alongside scientists in discovery, and clinical groups to design new experiments, analyze and interpret data, and effectively communicate results. Data analysis will focus on systems biology and network pharmacology. Impactful results will be used in determining the efficacy and safety of compounds, impacting dose decisions, selecting novel indications for targets and compounds, biological interpretation of results, and the identification of prediction biomarker for patient stratification and precision medicine. The successful candidate will represent the department on cross-functional disease focused teams.

Team members are encouraged to publish and to develop and maintain a strong professional network within the internal and external scientific communities.

J2W:LI

J2W:BIO

J2W:NSJ

Qualifications

The successful candidate will have at a minimum a PhD degree in Systems Biology, Immunology, Epidemiology, Statistics, Computational Biology, Bioinformatics or related field combined with a minimum of 4 years of academic and/or industry experience. The ability to apply data mining, machine learning, and emergent algorithms to pre-clinical, clinical and health outcomes data is required. Experience in network analysis and/or modeling biological pathways is preferred.

Experience in handling exploratory data such as microarrays, protein arrays, ELISA, MS or NGS is required. Proficiency in software such as SAS, S-PLUS, R, Omicsoft, Cytoscape is desired. A strong publication track record is desired. The ability to work independently, communicate clearly, collaborate effectively and establish effective and trusted partnerships with internal and external scientists is essential.

This position is based in La Jolla, CA and may require up to 5% travel (domestic & international).

BE VITAL in your career, Be seen for the talent you bring to your work. Explore opportunities within the Johnson & Johnson Family of Companies.

Primary Location:North America-United States-California-San Diego

Organization: Janssen Research & Development, LLC. (6084)

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Computational Biologist

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. The Computational Biologist performs biological sequence searches related to the operation of a large scale, high throughput DNA mapping and DNA sequencing production facility.

Qualifications:

Education, Training and Experience
Graduation from a recognized Bachelor of Science Program in either Biological Sciences or Computer Science.
Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

Experience with relevant operating systems.
Demonstrated interpersonal skills including the ability to work effectively with others in a team environment
Demonstrated ability to efficiently organize work assignments and establish priorities.
Ability to use related equipment.

We invite you to apply by clicking the "Apply Online Now" button where you can register for the first time or enter your Username and Password in order to re-access your profile on our system.

Applications will be accepted until this position has been filled.

For more information on all that the PHSA has to offer, please visit: http://careers.phsa.ca

For more information about the BC Cancer Agency, please visit the website at:www.bccancer.ca

Internal competition closes September 8, 2013. Internal applications received after this date will be considered as late applications.

***Employees of PHSA must apply via the "Internal Application Process". Current PHSA staff who apply to this posting using this external site will be considered with other external candidates. Seniority will not apply.***

The PHSA is committed to employment equity and hires on the basis of merit. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities.

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Project	Post Name	Qualification
PPV&FRA	SRF	M.Sc in Genetics/M.Sc in Agri /M.Sc Botany/M.Sc agriculture Botany .Desirable : Experience in handling of crop plants
NIFBSFARA		M.Sc /M.Sc in Agri /MA in RS & GIS/Geography/Botany.Desirable : Work Experience in ERDAS Imagine, ARCGIS, GPS use in Grasslands identification, characterization an mapping , geo processing, GDB creation and wide experience of GT using GPS etc.
ICAR		M.Sc Agri/M.Sc in following subjects Agronomy/ Soil Science/Soil and Water Conservation /Agro forestry Plant Physiology/Agri Extension/Botany or B.tech (Agricultural Engineering ) Or other allied subjects. Desirable: M.tech (Soil Water Conservation/ Engineering/Water Resource Develop,emt/Irrigation and Drainage Engineering) Experience of working in On -Farm projects.
DBT	JRF	M.Sc. in Biotechnology/Molecular biology /Biochemistry.Desirable: Experience in Tissue culture/gene cloning/ Bioinformatics/ Transformation work in crop plants.

Age : 35 yrs for men and 40 yrs for women candidates

No.of Post: 1

Pay Scale : Rs.16000

How to apply:

The candidates may come along with their application & Bio-data on plain paper with passport size photograph, attested copies of mark sheets and certificates and produce original at the time of interview.

Post Name	Post Name	Date & Time
PPV&FRA	SRF	12/09/2013 at 10.00 AM
NIFBSFARA	SRF	13/09/2013 at 10.00 AM
ICAR	SRF	16/09/2013 at 10.00 AM
DBT	JRF	18.09.2013 at 10.00 AM