TCAG, The Centre for Applied Genomics at The Hospital for Sick Children, is one of the leading genomics centres in the world. The TCAG informatics facility is involved in computationally challenging problems such as de-novo genome assembly, identification of potentially pathologic single nucleotide variants utilizing exome or whole-genome re-sequencing and copy number variant detection. TCAG also supports the Database of Genomic Variants (DGV), the major copy number variation database. The Hospital for Sick Children is one of the leading paediatric health care centres in the world with an international reputation for excellence in health care, research, and teaching.
Responsibilities
We are seeking a highly motivated bioinformatics analyst to run and extend analysis pipelines for human/mammalian NGS (next generation sequencing) data, with a specific focus on variant detection in exome and whole genome resequencing applications.
The position will report directly to the informatics core facility manager and will involve close interactions with other informatics facility members.
Requirements
The candidate will have a M.Sc. or equivalent degree in Bioinformatics, Computational Biology, Computer Science, Biomedical Engineering or related fields. Previous experience with NGS data analysis, solid knowledge of scripting languages (Perl, Python, R or Ruby), SQL and Unix OS are strictly required. Excellent communication and team work skills are also required. Strong preference will be given to Canadian citizens, permanent residents as well as graduates of a Canadian institution eligible for a post-graduation work permit.
Preferences
Previous experience exome/whole genome read alignment and variant detection tools is a plus.
Locale
The work will be conducted at the TCAG/The Hospital for Sick Children, Toronto. Toronto is a major international centre of genomics, proteomics and systems biology research; there will ample opportunity for professional development through research seminars, workshops and research in progress meetings.
Compensation
Salary is commensurate with education and qualifications.
Terms
Fixed-term, 2 year contract, with the possibility of extension. TCAG is strongly committed to provide continuative funding for bioinformatics personnel with a good performance record.
Our team are currently working on antibody sequencing using the Database Assisted Shotgun Sequencing (DASS) technology. We are also looking for a reliable data analyzing tool. Without a proper tool, we can get nothing.
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